Endocrine Abstracts

Thyroid eye disease (TED), or Graves’ orbitopathy, is a common manifestation of autoimmune thyroid disease, affecting up to 30% of patients. Prompt identification of the development of TED is often difficult as the underlying inflammation of the orbital tissues and can lead to a wide range of symptoms and signs.These include extraocular muscle fibrosis leading to diplopia, orbital congestion leading to optic nerve compression and lid retraction lead...

Introduction: One of the most promising potential targets for new treatments in Graves ophthalmopathy (GO) is the insulin-like growth factor 1 receptor (IGF1R). However, a significant impediment to the translational pathway in developing new treatments for GO is the lack of any animal or in vitro model.Aims: To characterise dysregulation of IGF1 pathway related gene expression in GO. To develop a new in vitro model for tissue expansion in G...